85例丙型肝炎患者临床与流行病学分析

Clinical and epidemiological features of 85 cases with hepatitis C

目的观察晋城市第三人民医院丙型肝炎患者的临床与流行病学的特征。方法对晋城市第三人民医院2010年3月至2014年3月收治的85例丙型肝炎患者的资料进行回顾调查分析及调查问卷,从传播途径、实验室检查、临床表现等方面进行分析。结果 85例患者中,有输血及血液制品史的57例,占总病例的67.1%。HCV RNA载量以10^4-10^7拷贝/ml居多,共57例,占总病例数的67.1%。经非参数检验显示,除ALT水平外（χ^2=5.259,P=0.022）,其余因素均与性别无相关性,差异无统计学意义（P均〉0.05）。结论丙型肝炎病程长,病情较隐匿,大多数患者临床症状及体征不明显,需尽早积极抗病毒治疗,以减少肝硬化及肝癌的发生。

Objective To investigate the characteristics of clinical and epidemiological of patients with hepatitis C in the Third People＇s Hospital of Jincheng. Methods The clinical data of 85 patients with hepatitis C treated in our hospital from March 2010 to March 2014 were analyzed, retrospectively and the questionnaire from the aspects of communication, laboratory examination, clinical manifestation were administered. Results Among the 85 patients, there were 57 cases（67.1%） with the history of blood transfusion and blood products in the transmission way. For the laboratory examination, a total of 57 cases（67.1%） with HCV RNA load as 10^4-10^7 copies/ml. The nonparametric test showed that the factors were not related to gender（P all〉 0.05）, except for the levels of ALT（χ^2 = 5.259, P = 0.022）. Conclusions The course of the hepatitis C was long and the condition was relatively hidden, most of the clinical symptoms and signs of the patients were not sinificant. In order to reduce the incidence of liver cirrhosis and hepatocellular carcinoma, the actively antiviral treatment should be taken as early as possible.