IL-22、IL-27、VEGF、TF及TFPI鉴别良恶性胸腔积液的应用价值研究

Study on application value of IL-22,IL-27,VEGF,TF and TFPI in identification of benign and malignant pleural effusion

目的探讨白细胞介素(IL)-2、IL-27、血管内皮生长因子(VEGF)、组织因子(TF)及组织因子途径抑制物(TFPI)鉴别良恶性胸腔积液的应用价值。方法采用酶联免疫吸附测定(ELISA)法检测67例良性胸腔积液及73例恶性胸腔积液的IL-22、IL-27、VEGF、TF及TFPI 5种分子标志物的水平。结果恶性胸腔积液组的IL-22、IL-27、VEGF、TF及TFPI水平均显著高于良性胸腔积液组,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,只有VEGF是胸腔积液良恶性鉴别的独立影响因素。结论胸腔积液IL-22、IL-27、VEGF、TF及TFPI的检测有助于临床诊治良恶性胸腔积液患者,其中VEGF可做为胸腔积液良恶性鉴别的独立影响因素。

Objective To explore the application value of IL-22,IL-27,VEGF,TF and TFPI in the identification of benign and malignant pleural effusion.Methods The enzyme-linked immunosorbent assay（ELISA）was adopted to detected the five molecular markers levels of IL-22,IL-27,VEGF,TF and TFPI levels in 67 cases of benign pleural effusion and 73 cases of malignant pleural effusion.Results The levels of IL-22,IL-27,VEGF,TF and TFPI in the malignant pleural effusion group was significantly higher than those in the benign pleural effusion group,and the differences were statistically significant（P0.05）.The multi-factor Logistic aggression analysis results showed that only VEGF was an independent influencing factor for identifying benign and malignant pleural effusion.Conclusion The detection of pleural effusion IL-22,IL-27,VEGF,TF and TFPI is helpful for clinical diagnosis and treatment of the patients with benign and malignant pleural effusion,in which VEGF can be regarded as an independent factor influencing the identification of benign and malignant pleural effusion.