HbALC、U-mALB、UAL/Cr检测在2型糖尿病肾病诊断中的意义及其相关性分析

Significance and correlation analysis of Glycosylated Hemoglobin,Urine Albumin and Urine Albumin Creatinine ratio in diagnosis of type 2 diabetic Nephropathy

目的探讨糖化血红蛋白(Hb ALC)、尿微量白蛋白(U-mALB)、尿微量白蛋白肌酐比值(UAL/Cr)检测在2型糖尿病肾病诊断中的临床意义。方法选取2型糖尿病肾病患者(DN组)105例,单纯2型糖尿病患者(DM组)123例、健康检查者(对照组)59例,分析各组间Hb ALC、U-mALB、UAL/Cr水平差异,并对各指标进行回归性分析。结果 DN组的Hb ALC、UmALB、UAL/Cr水平均高于DM组与对照组(P均<0.05);DM组Hb ALC水平高于对照组(P<0.05),DM组U-mALB、UAL/Cr水平与对照组无明显差异。结论糖尿病肾病会引起U-mALB、UAL/Cr水平改变,但在单纯组无明显改变,以其作为糖尿病肾病的早期筛查指标优于Hb ALC检测,U-mALB、UAL/Cr对2型糖尿病肾病的早期发现、诊断、治疗和监测具有重要的临床意义。

Objective To investigate the clinical significance of glycosylated hemoglobin （HbALC）, urinary albumin （U- mALB） and urinary albumin creatinine ratio （UAL/Cr） in the diagnosis oftype 2 diabetic nephropathy. Methods Collecting 2 patients with type 105 diabetic nephropathy （DN group）, 2 patients with type diabetes mellitus （DM group）, 123 cases of health ex-amination （control group） 59 cases In 2015 1-6 months, The differences of U-mALB, UAL/Cr and HbALC were analyzed, and the regression analysis was carried out.,and Regression analysis of all indexes. Results The levels of UAL/Cr, U-mALB and HbALC in DN group were significantly higher than those in DM group and control group, and the difference was statistically significant （P 〈0.05）; The levels of HbALC in DM group were significantly higher than those in control group （P〈0.05）, and there was no signif-icant difference between U-mALB and DM in UAL/Cr group and control group. Conclusions Diabetic nephropathy can cause changes in U-mALB and UAL/Cr levels, but it is no difference in DM group,so U-mALB and UAL/Cr are better than HbALC, U-mALB and UAL/Cr in the early detection of diabetic nephropathy, and it has important clinical significance for early detection, diagnosis, treatment and monitoring of type 2 diabetic nephropathy.