儿童静脉注射丙种球蛋白治疗不敏感川崎病16例的临床特点及效果分析

Analysis of the clinical characteristics and effect of Kawasaki disease with insensitivity for intravenous injection gamma globulin in 16 cases of children

目的:探讨丙种球蛋白不敏感川崎病的临床特点及治疗效果。方法:收治216例川崎病患儿,其中对丙种球蛋白不敏感16例,分析其临床特点及治疗效果。结果:敏感组和不敏感组在血沉、乳酸脱氢酶、C反应蛋白、血红蛋白、白细胞总数方面比较,差异无统计学意义(P>0.05),而在白蛋白指标方面比较,差异有统计学意义(P<0.05),经过治疗,白细胞总数、C反应蛋白和血沉明显降低(P<0.05),血红蛋白和血细胞比容变化,差异无统计学意义(P>0.05)。结论:男性患儿发病率较高,冠状动脉病变发生率高是丙种球蛋白不敏感川崎病的临床特点,阿司匹林联合丙种球蛋白治疗疗效确切。

ObjectiveTo explore the clinical characteristics and effect of Kawasaki disease with insensitivity for intravenousinjection gamma globulin.Methods：216 cases of children with Kawasaki disease were selected.Among them,16 cases was notsensitive for gamma globulin.We analyzed the clinical characteristics and treatment effect.Results：In the sensitive group and thenon sensitive group,there were no statistically significant differences in the erythrocyte sedimentation rate,lactate dehydrogenase,C reaction protein,hemoglobin and total number of white blood cells（P〉0.05）,but there was significant difference in albuminindex（P〈0.05）.After treatment,the total number of white blood cells,C reactive protein and erythrocyte sedimentation rate weresignificantly decreased（P〈0.05）,and there were no significant differences in hemoglobin and hematocrit changes（P〉0.05）.Conclusion：The incidence of males was higher,the high incidence of coronary artery disease was a clinical feature of Kawasakidisease with insensitivity for intravenous injection gamma globulin.The curative effect of aspirin combined with gamma globulinwas exact.