“聚集诱导发光的基本科学问题”研究4年度报告

The Annual Report of Project No.4 of the “Basic Scientific Problems of AggregationInduced Emission” 973 Program

该研究通过AIE小分子/高分子的官能化,形成基于AIE原理的化学与生物检测技术,观察到修饰后的AIE分子对蛋白质、酶、DNA、RNA等生物分子的特异响应,实现了深红/近红外荧光的AIE材料在活性细胞与生物体内的应用,同时开展了AIE材料新结构的开发以及应用领域的扩展研究工作。

In this year, we achieved the following progresses：（1）the introduction of the functional groups into AIE compounds;（2）the fabrication of novel AIE system with the mechanochromic properties;（3）the application of AIE compounds for studying the motions of polymeric chains;（4）the application of AIE compounds as biosensors for detection of proteins, enzyme, DNA, RNA and etc.;（5）the application of carmine/NIR AIE compounds for active cells and biosystems. We published 14 peer-reviewed papers and wrote 3 chapters for a Wiley book ＂Aggregation-Induced Emission＂. We gave 3 invited talks on international conference. 4 Ph D and 6 MS students graduated.