武汉地区近5年HCV流行病学特征分析

Analysis on epidemiological characteristics of HCV in Wuhan City in recent five years

目的了解武汉地区丙型肝炎病毒(HCV)流行病学特性,对HCV感染采取有效的预防和控制策略提供科学的理论依据。方法收集2011年1月—2015年12月武汉大学人民医院检验科进行抗-HCV筛查的人群基本信息,并记录抗-HCV,HCV-RNA载量和HCV基因型结果。结果 2011—2015年间HCV感染率比较,差异无统计学意义(χ2=2.94,P=0.568)。各年龄段的男女感染率比较,差异有统计学意义(χ2=76.00,P<0.01)。男性HCV感染者各年龄段抗-HCV水平间比较,差异无统计学意义(F=1.06,P=0.390);而女性HCV感染者各年龄段抗-HCV水平间比较,差异有统计学意义(F=4.67,P<0.01)。武汉地区以1 b基因型最多(71.98%),2 a型次之(17.14%),未发现4、5型基因。结论 HCV感染与年龄和性别具有一定关系。

[Objective]To analyze epidemiological characteristics of hepatitis C virus（HCV）in Wuhan City provide a scientific basis for carrying out the effective prevention and control strategies.[Methods]The essential information of people who have received the anti-HCV screening in the Department of Laboratory Science of Renmin Hospital of Wuhan University from January2011 to December 2015 were collected,while the anti-HCV,HCV RNA load and HCV genotype were recorded.[Results]There was no statistically significant difference in the annual infection rate of HCV from 2011 to 2015（χ2 =2.94,P =0.568）. The difference in the infection rate was statistically significant between males and females in all age groups（χ2=76.00,P〈0.01）. There was no statistically significant difference in anti-HCV level among different age groups in males（F =1.06,P =0.390）,while the difference among different age groups in females was statistically significant（F =4.67,P〈0.01）.The genotype 1b was most（71.98%）,followed by genotype 2 a,and genotype 4 and 5 was not found in Wuhan City.[Conclusion]HCV infection has a certain relationship with age and gender.