喘息婴幼儿外周血白介素-17、白介素-23、趋化因子配体10的测定及意义

Determination and significance of peripheral IL-17,IL-23 and CXCL10 in wheezing infants

目的探讨喘息婴幼儿外周血白介素-17(IL-17)、白介素-23(IL-23)、趋化因子配体10(CXCL10)的变化及其意义。方法酶联免疫吸附法测定36例喘息患儿、24例非喘息患儿及20例健康组外周血IL-17、IL-23、CXCL10的含量,并进行两两比较。结果喘息组、非喘息组和健康组的外周血IL-17、IL-23、CXCL10的含量,采用单因素方差分析,差异有统计学意义(P<0.05);经方差分析的两两比较(LSD法),喘息组和非喘息组的外周血IL-17、IL-23、CXCL10的含量分别与健康组比较,差异有统计学意义(P<0.05),喘息组外周血IL-17及CXCL10含量高于非喘息组(P<0.05),喘息组外周血IL-23含量与非喘息组比较,差异无统计学意义(P>0.05)。结论 IL-17、IL-23及CXCL10在喘息患儿外周血中的含量表达升高,可能参与婴幼儿喘息的发病机制。

Objective To explore the changes and significance of peripheral IL-17, IL-23 and CXCL10 in wheezing infants. Methods Plasma IL-17, IL-23 and CXCL10 in 36 cases of children with wheezing, 24 cases of non-wheezing children and 20 healthy infants were determined by ELISA and compared. Results Compared with the healthy controls, the levels of IL-17, IL-23 and CXCL10 were significantly increased in the wheezing group and the non-wheezing group （P〈 0.05）. Compared with the non-wheezing group, the levels of IL-17 and CXCL10 increased in the wheezing group （P〈 0.05）; there was no statistical significance in IL- 23 between the wheezing and non-wheezing groups （P〉 0.05）. Conclusions The levels of IL-17, IL-23 and CXCL10 increase in wheezing infants, indicating that they may participate in pathogenesis of wheezing in infants.