荧光探针在胃癌靶向治疗中的研究进展

The progress of fluorescent probes in the targeted therapy of gastric cancer

胃癌已经成为我国最常见的消化道恶性肿瘤,尽管随着医疗技术水平的发展,胃癌的治疗效果有一定的提高,但是总体情况仍达不到令人满意的程度。近年来,荧光探针技术以及分子靶向治疗的不断发展使患者在低细胞毒性下接受治疗,通过荧光探针标记物可与胃癌细胞靶向基因结合,从而在指定设备作用下激发结合物,可以使患者体内胃癌组织在光照作用下发出荧光,术者可以根据荧光显像的位置判断有无淋巴结转移,精准切除胃癌组织。本文概述荧光探针与胃癌靶向基因结合后用于胃癌细胞的检测、有无淋巴结转移以及肿瘤组织精准切除的应用前景。

Gastric cancer has become one of the most common gastrointestinal malignancy in our country, with the development of medical technology, although the treatment effect of gastric cancer is improved, the overall situation is still not reach the satisfactory level. In recent years, with the development of fluorescent probe techniques and molecular targeted therapy, gastric cancer patients can be treated under the small cell toxicity, markers can be targeted gene and gastric cancer cells by fluorescent probes, we can use specified device to inspire combination, that the gastric cancer cells would fluoresce under the effect of light. According to the location of the fluorescence imaging, the doctor can judge the presence of lymph node metastasis and remove gastric cancer tissue accurately. This paper reviewed the pros- pect of gastric cancer cells combined with targeted gene, the technology used in the detection of gastric cancer cells, with or without lymph node metastasis and accurate resection of tumor tissue.