长期使用质子泵抑制剂与小肠细菌过度生长的关系研究

Relationship between the long-term use of PPIs and the small intestinal bacterial overgrowth

目的探讨长期使用质子泵抑制剂(proton pump inhibitors,PPIs)与小肠细菌过度生长(small intestinal bacterial overgrowth,SIBO)的关系。方法选取北大医疗鲁中医院符合纳入及排除标准的反流性食管炎(reflux esophagitis,RE)患者120例,以及健康对照人群60名,通过乳果糖氢呼气试验(lactulose hydrogen breath test,LHBT)诊断SIBO。结果 RE组与健康对照组在年龄、性别分布上差异无统计学意义(P>0.05);服药前RE组的SIBO阳性率为11.67%,而健康对照组为10.00%,两组SIBO发生率差异无统计学意义(P=0.056);64例患者坚持服用PPIs 8周,服药前SIBO的阳性率为12.50%,服药后则上升至53.13%,差异具有统计学意义(P=0.001)。结论应用PPIs 8周后,RE患者的SIBO阳性率较服药前显著升高,PPIs的应用与SIBO发生有关。

Objective To explore the relationship between the long-term use of proton pump inhibitors （PPIs） and small intestinal bacteria growth （SIBO）. Methods 120 reflux esophagitis （RE） patients from PKU Care Luzhong Hos- pital who met the inclusion and exclusion criteria and 60 healthy volunteers were collected. The SIBO was diagnosed by lactulose hydrogen breath test （LHBT）. Results Before taking the medicine, the rate of SIBO was 11.67% in observation group and 10.00% in the healthy group （P = 0. 056）. The rate of SIBO of 64 patients taking PPIs consistently for 8 weeks was 53.13% , higher than that before taking medicine 12.50% （P =0. 001 ）. Conclusion After 8 weeks use of PPIs, the positive rate of SIBO in patients with RE was significantly higher than that before treatment, and the application of PPIs is related to the occurrence of SIBO.