复方丹参滴丸治疗早期糖尿病肾病的临床分析

Clinical Analysis of Compound Danshen Dropping Pill in the Treatment of Early Diabetic Nephropathy

目的:观察复方丹参滴丸治疗早期糖尿病肾病的效果。方法:采用多中心、前瞻性、随机分组,开放、平行及前后对照的观察性研究,选取2012年1月-2013年1月在丹东各级医院就诊的2型糖尿病合并早期肾病的患者,共74例,随机分为治疗组(n=53)和对照组(n=21)。在合理降糖、降压和降脂等综合治疗基础上,治疗组加用复方丹参滴丸,15粒/次,3次/d;对照组保持原治疗方案不变,观察期共24周。观察治疗前后两组患者血糖、Hb A1c及尿微量白蛋白/尿肌酐的变化。结果:治疗后两组患者尿微量白蛋白/尿肌酐均较治疗前明显下降,差异均有统计学意义(P<0.05),治疗组患者尿微量白蛋白/尿肌酐较对照组呈明显下降趋势,但两组比较差异无统计学意义(P>0.05)。结论:在原治疗方案不变的情况下,复方丹参滴丸在短期内(24周)可使早期糖尿病肾病的尿微量白蛋白/尿肌酐呈下降趋势。

Objective： To observe the clinical effect of Compound Danshen Dropping Pill in the treatment of early diabetic nephropathy.Method： A total of 74 type 2 diabetes mellitus （ T2DM ） patients with diabetic nephropathy （ DN ） who met the criteria for DN from January 2012 to January 2013, were retrospectively analyzed and randomized into the treatment group （ n=53 ） and the control group （ n=21 ） .All patients received rational hypogiyeemic, step-antihypertensive, lipids-adjusting treatment and the treatment group received Compound Danshen Dropping Pill （ 15 pills, tid ）, add itionally.Laboratory indexes such as blood glucose, HbAlc, and urine trace albumin/ creatinine were examined 24 weeks after treatment.Result： The levels of urine trace albumin/ereatinine of two groups were decreased after versus before treatment （ P〈0.05 ）, but the decreases of urine trace albumin/ereatinine had not significant differences between two groups （ P〉0.05 ） .Conclusion： The eomprehend-sive treatment combined with Compound Danshen Dropping Pill for 24 weeks can effectively reduce urine trace albumin/createnine