毛郁金化学成分的分离与鉴定

Isolation and identification of the chemical constituents from the rhizomes of Curcuma aromatica Salisb.

目的对毛郁金的化学成分进行研究。方法采用硅胶柱色谱、氧化铝柱色谱、ODS柱色谱和制备高效液相色谱等方法分离纯化毛郁金的化学成分,通过波谱数据分析确定化合物的结构。结果从毛郁金乙酸乙酯萃取物中分离得到10个化合物,分别鉴定为莪术二酮(curdione,1)、新莪术二酮(neocurdione,2)、吉马酮-4,5-环氧化物(germacrone-4,5-epoxide,3)、莪术二酮-1,10-环氧化物(curdione-1,10-epoxide,4)、gajutsulactone A(5)、莪术双环烯酮(curcumenone,6)、polydactin B(7)、4,5-seco-4,5-dioxo-guaia-1(10),11-diene(8)、2-endo-hydroxy-1,8-cineole(9)、邻苯二甲酸二丁酯(dibutylphthalate,10)。结论化合物3、5、7-10为首次从该植物中分离得到,其中化合物7-10为首次从姜黄属植物中分离得到。

Objective To study the chemical constituents in the rhizomes of Curcuma aromatica. Methods Chromatographic methods were used for the isolation and purification, including silica gel, ODS, alumina and HPLC. The structures were identified on basis of spectroscopic analysis. Results Ten compounds were isolated from C. aromatica. They were identified as curdione （ 1 ）, neocurdione （ 2 ）, germacrone-4,5-epoxide （ 3 ）, curdione-1,10-epoxide （4）, gajutsulactones A （ 5 ）, curcumenone （ 6 ）, polydactin B （ 7 ）, 4,5-seco-4,5- dioxo-guaia-1 （ 10 ）, 11 -diene （ 8 ）, 2-endo-hydroxy-1,8-cineole （ 9 ）, and dibutylphthalate （ 10 ）. Conclusions Compounds 3,5,7-10 are isolated from this plant for the first time, and compounds 7-10 are obtained from the plants of Curcuma L. for the first time.