维、汉民族ACS患者NT-proBNP与左室射血分数间的相关性研究

Correlation study between NT-proBNP and Left ventricular ejection function in patients with acute coronary syndromes of Uighur and Han nationality

目的:分析急性冠状动脉综合征(ACS)患者血N末端脑钠肽前体(NT-proBNP)水平与左心室射血分数(LVEF)的关系,并探讨维、汉民族间血浆内NT-proBNP浓度的差异及其与左室射血功能的相关性。方法:选取的对象是2012-05-2014-09在新疆医科大学与第一附属医院冠心病一科住院的维吾尔族和汉族共531例ACS患者(维族239例、汉族292例),按族别分别包括不稳定型心绞痛(UA)、急性ST段抬高型心肌梗死(STEMI)、急性非ST段抬高型心肌梗死(NSTEMI),入院后即予NT-proBNP及LVEF检测,根据LVEF值分为A组(LVEF≥50%)和B组(LVEF<50%)。结果:维吾尔族与汉族ACS患者在一般情况上差异无统计学意义(P>0.05);但两组NT-proBNP中位数有差异;差异有统计学意义(P<0.05);A组NT-proBNP(830±404)pg/ml;B组NT-proBNP(8 892±2 333)pg/ml;A组血浆NT-proBNP与LVEF无明显相关性(r=-0.13,P=0.09),B组NT-proBNP水平与LVEF呈负相关(r=-0.735,P=0.008),即随着NT-proBNP水平的升高,LVEF逐渐下降,两民族间比较有统计学差异(P<0.05)。结论:维吾尔族患者NT-proBNP水平高于相应的汉族患者。当LVEF<50%时,NT-proBNP水平与LVEF呈负相关。对于ACS患者,NT-proBNP水平亦能反映心功能状态,且与LVEF综合应用,能更好地反映患者病情,对预后有指导意义。

Objective：To analysis NT-proBNP levels and LVEF in patients with acute coronary syndrome.Method：A total of 531 patients with acute coronary syndrome（239cases of Uighur and 292 cases of han ethnic group）was selected in this study,including unstable angina（UA）and acute ST segment elevation myocardial infarction（STEMI）,acute non ST segment elevation myocardial infarction（NSTEMI）.They were detected the NT-proBNP and LVEF.Result：Uighurs and Han Chinese patients with acute coronary syndrome in general data had no statistical significance（P〉0.05）.But there were differences in NT-proBNP median between two groups.NT-proBNP was 830±404pg/ml in LVEF≥50% group and 8892±2333pg/ml in LVEF〈50% group.In latter group,plasma NT-proBNP was negatively correlated with LVEF（r=-0.735,P=0.008）.Conclusion：NT-proBNP levels in Uighur patients are higher than those in Han patients.When LVEF〈 50%,the negative correlation with LVEF and NT-proBNP level is found in patients with acute coronary syndrome.