摘要
目的探索多b值扩散加权成像(DWI)的体素内不相干运动(IVIM)模型预测肾脏肾小球滤过率(GFR)的价值。方法纳入56例因蛋白尿或持续微量蛋白尿就诊的患者,根据估计肾小球滤过率(e GFR)将56例患者分成明显肾功能损伤组(sRI,e GFR≤30 m L/min/1.73 m^2)和非明显肾功能损伤组(non-sRI)。56例患者均完成7个b值DWI序列扫描。多b值DWI图像选择右肾中心层面勾画肾实质区为感兴趣区(ROI),然后行IVIM模型分析,分别得到3个参数:慢、快扩散系数(D_(slow)、D_(fast))和快扩散系数的分数(F_(fast))。结果 sRI组的3个IVIM参数均小于non-sRI组(t≥3.793,P<0.05),3个参数均与e GFR呈线性相关(r>0.357,P<0.05)。当区分sRI和non-sRI组时,3个参数的受试者工作特征曲线(ROC)下面积没有明显差异(Z≤0.482,P>0.05)。结论基于IVIM模型分析的多b值DWI具有预测GFR的潜力。
Objective To determine the value of intra-voxel incoherent motion (IVIM) based diffusion weighted imaging in the assessment of renal glomerular filtration rate in vivo. Methods Fifty-six consecutive participants with albuminuria or persistent micro-albuminuria were recruited into this study. The estimated glomerular filtration rate (eGFR) was calculated to classify the participants as having severe renal injury (sRI, eGFR ≤ 30 mL/min/1.73 m^2) or not (nonsRI). DWI with seven b-factors was performed. Image analysis was performed by a radiologist to generate diffusion coefficient ( Dslow and Dfast, ) and fraction of fast diffusion ( Ffast ) maps using IVIM model. The regions of interest were curved to cover the renal parenchyma for parameter measurements. Results The D jow, Draft and Ffast were less in sRI than non-sRI (t 〉13. 793. 547 ,P 〈 0.05 ), and positively related with eGFR ( r 〉 0. 357, P 〈 0.05 ). For differentiating sRI from nonsRI, receiver operating characteristic curve indicated no significant difference between the three parameters (Z ≤0. 482, P 〉 0. 05). Conclusion The IV1M model based diffusion weighted imaging has the potential for assessing renal glomerular filtration rate in vivo.
作者
杨莹
俞胜男
蒋振兴
丁玖乐
陈杰
邢伟
YANG Ying YU Shengnan JIANG Zhenxing et al(Department of Radiology, the First Hospital of Changzhou, Jiangsu 213003, P. R. China)
出处
《临床放射学杂志》
CSCD
北大核心
2016年第11期1690-1692,共3页
Journal of Clinical Radiology
关键词
肾脏
肾功能
磁共振成像
扩散加权成像
Kidney Renal function Magnetic resonance imaging Diffusion weighted imaging