摘要
Nesfatin一1是一种新发现的摄食抑制性脑肠肽，在中枢神经系统和多个外周组织中均有表达。Nesfatin一1基因多态性或蛋白表达异常均可能引发摄食增多和肥胖。Nesfatin一1可直接作用于摄食相关神经元，减轻肥胖程度；也可通过影响催产素、神经肽Y等神经肽的表达和功能，间接发挥降低体重的作用。
Nesfatin-1 is a novel anorexigenic brain-gut peptide and expressed in central nerve system and multiple peripheral tissues. Polymorphism and abnormal protein expression of nesfatin-1 might lead to hyperphagia and obesity. Nesfatin-1 not only directly abates obesity by influencing feeding-related neu- rons, but also indirectly decreases body weight by affecting the expressions and functions of many neuropep- tides, such as oxytocin, neuropeptide Y, and so on.
出处
《国际内分泌代谢杂志》
2016年第6期384-387,共4页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金青年项目（81500414）
山东省优秀中青年科学家科研奖励基金（BS2014YY009）
