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MC4R在肥胖及糖代谢中的作用 被引量：1

Role of MC4R in obesity and glucose metabolism
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摘要 黑皮质素受体4（MCAR）可通过作用于中枢阿片一促黑素细胞皮质素原（POMC）神经元、交感节前神经元、以及与其激动剂的相互作用，调控食物摄入和能量消耗，进而改善肥胖。此外，MC4R还可参与胰岛素敏感性及葡萄糖稳态的调控，为肥胖及糖尿病的治疗提供新靶点。 Melanocortin 4 receptor （MCAR） plays a major role in food intake and energy expenditure regulation by interacting with pro-opiomelanocortin （POMC） neurons, sympathetic preganglionie neurons and its agonists, thus improves obesity. In addition, MC4R also mediates the regulation of insulin sensitivity and glucose homeostasis, providing new target for the treatment of obesity and diabetes.
作者 刘玉洁 杨曦 马慧娟
机构地区 河北医科大学研究生学院 河北医科大学内科学教研室 河北省人民医院内分泌科
出处 《国际内分泌代谢杂志》 2016年第6期391-393,共3页 International Journal of Endocrinology and Metabolism
关键词 黑皮质素受体4 肥胖症 糖代谢 Melanocortin 4 receptor Obesity Glucose metabolism
分类号 R589.2 [医药卫生—内分泌]
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  • 1Santoro N,Cirillo G,Xiang Z,et al. Prevalence of pathogenetic MC4R mutations in Italian children with early onset o besity, tall stature and familial history of obesity[J].BMC Med Genet,2009,10 : 1471-2350.
  • 2Lubrano-Berthelier C, Dubern B, Lacorte JM, et al. 2006 Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationships, and lack of association with binge eating [J].J Clin Endocrinol Metab, 2006,91 : 1811-1818.
  • 3Lee YS,Poh LK,Kek BL,et al. Novel melanocortin 4 recep tor gene mutations in severely obese children[J]. Clin Endoerinol(Oxf), 2008,68 : 529-535.
  • 4Hinney A, Schmidt A, Nottebom K, et al. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans [J].J Clin Endocrinol Metab, 1999,84 : 1483-1486.
  • 5Hinney A, Hohmann S,Geller F, et al. Melanocortin 4 receptor gene:ease-control study and transmission disequilibri urn test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity[J].J Clin Endoerinol Metab, 2003,88 : 4258-4267.
  • 6Donohoue PA, Tao YX,Colins M,et al. Deletion of codons 88-92 of the melanocortin-4 receptor gene: a novel deleterious mutation in an obese female [J]. J Clin Endocrinol Metab,2003,88:5841- 5845.
  • 7Tao YX, Segaloff DL. Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity[J]. Endocrinology, 2003,144 :4544- 4551.
  • 8Dubern B, Bisbis S, Talbaoui H, et al. Homozygous null mutation of the melanocortin-4 receptor and severe early-on- set obesity[J]. J Pediatjr, 2007,150 : 613-617.
  • 9Stutzmann F, Cauchi S, Durand E, et al. Common genetic variation near MC4R is associated with eating behaviour patterns in European populations[J]. Int J Obes (Lond), 2009, 33,373-378.
  • 10Wraight, Yuan X, Zeggini E, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity[J].Nat Genet, 2008,40 : 768-775.

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国际内分泌代谢杂志
2016年 第6期

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