硒蛋白S与糖尿病及大血管并发症

Relationship between selenoprotein S, diabetes and its macrovascular complications

硒蛋白s为一种膜蛋白，其组织分布广泛，与炎性反应、氧化应激及内质网应激关系密切。研究发现，不同组织的硒蛋白s在糖尿病及其大血管并发症发生、发展中的作用不同。胰腺及血管中的硒蛋白S发挥抗氧化及抗内质网应激的保护效应，而肝脏、脂肪组织及骨骼肌中的硒蛋白S反而促进糖尿病及胰岛素抵抗的发生、发展。因此，全面地剖析硒蛋白s在各组织中的作用特点及机制，可为糖尿病及其大血管并发症提供新的防治策略。

Selenoprotein S is identified as a transmembrane protein and expressed in numberous tissues. It is closely related to inflammatory response, oxidative stress and endoplasmic reticulum stress. Sele- noprotein S in different tissues has been suggested to play different roles in the pathogenesis and progression of diabetes and its maerovaseular complications. Selenoprotein S in pancreatic and vascular exerts anti-oxida- tive and anti-endoplasmie retieulum stress capacity, while selenoprotein S in liver, adipose tissue and skele- tal muscle can promote the pathogenesis and progression of diabetes and insulin resistance. Thus, analyzing the function and mechanism of selenoprotein S in various tissues comprehensively can provide new strategies for the prevetion and treatment of diabetes and its maerovaseular diseases.