菲并吲哚里西啶生物碱及其盐类衍生物的抗病毒活性和构效关系研究

Antiviral activity and SAR studies of phenanthroindolizidine alkaloids and their salt derivatives

本文研究了菲并吲哚里西啶生物碱1～17和（S）-6-O-脱甲基安托芬的盐类衍生物18～31对烟草花叶病毒的抗病毒活性和构效关系.发现其中部分化合物表现出很高的体内和体外抗病毒活性,尤其是（R）-6-O-脱甲基安托芬（14）和（S）-6-O-脱甲基安托芬氢碘酸盐（18）表现出了比商品化抗病毒剂宁南霉素更高的抗病毒活性,可以作为潜在的抗植物病毒剂.

The phenanthroindolizidine alkaloids 1–17 and their salt derivatives 18–31 were evaluated for antiviral activity against tobacco mosaic virus（TMV）, and the structure-activity relationship（SAR） were studied. Many of these compounds exhibited higher antiviral activity than commercial Ningnanmycin both in vitro and in vivo. Especially,（R）-6-O-desmethylantofine（14） and（S）-6-O-desmethylantofine hydriodate（18） showed excellent antiviral activity and could be considered for novel therapy against plant virus infection.