精神分裂症患者血清超敏C反应蛋白水平研究

Study of the serum level of high sensitivity C-reactive protein in schizophrenic

目的：研究精神分裂症患者血清超敏C反应蛋白（ hs-CRP）水平以及抗精神病药物对hs-CRP水平的影响。方法：采用颗粒增强免疫透射比浊法检测106例首次发病精神分裂症患者（首次发病组）、138例长期服用抗精神病药物治疗患者（长期服药组）和137名体检正常健康成人（对照组）血清hs-CRP水平,比较3组差异,并对单独服用氯氮平和利培酮治疗的患者血清hs-CRP水平进行分析。同时采集标本当天对精神分裂症患者进行阳性和阴性症状量表（ PANSS）评分。结果：长期服药组血清hs-CRP水平明显高于对照组（P〈0.01）,同时长期服药组血清hs-CRP水平高于首次发病组（P〈0.05）；氯氮平治疗组血清hs-CRP水平均明显高于利培酮治疗组和首次发病组（P〈0.01）,利培酮治疗组和首次发病组血清hs-CRP水平差异无统计学意义（P〉0.05）；hs-CRP〉2.0664 mg/L精神分裂症患者PANSS阳性量表分、阴性量表分、一般病理量表分和总分均高于hs-CRP〈2.0664 mg/L组（P〈0.05～P〈0.01）,相关性分析表明血清hs-CRP的表达与精神分裂症的病情均呈正相关关系（P〈0.05）。结论：精神分裂症患者血清hs-CRP水平明显升高,氯氮平治疗能上调hs-CRP的水平,hs-CRP水平与精神分裂症的病情具有相关性。

Objective：To investigate the level of serum high sensitivity C reactive protein（hs-CRP） in schizophrenic,and effect of antipsychotic drugs on the level of hs-CRP. Methods：The serum levels of hs-CRP in the first onset 106 schizophrenia patients（ the first onset group） ,108 patients treated with antipsychotic drugs（ long-term medication group） and 137 healthy people（ control group） were detected,the difference of which was compared. The serum levels of hs-CRP in patients treated with individual clozapine and risperidone were analyzed. The scores of the positive and negative syndrome scale（ PANSS） in schizophrenia patients was investigated. Results：The serum level of hs-CRP in long-term medication group was significantly higher than that in control group（P〈0. 01）,and the serum level of hs-CRP in long-term medication group was higher than that in the first onset group（P 〈0. 05）. The serum level of hs-CRP in clozapine group was significantly higher than that in risperidone group and the first onset group（P〈0. 01）. The difference of the hs-CRP level between the risperidone group and first onset group was not statistically significant（P〉0. 05）. The scores of the positive scale and negative scale of PANSS,general pathology scale and total score in schizophrenia patients with hs-CRP〉2. 066 4 mg/L were significantly higher than those in patients with hs-CRP 〈 2. 066 4 mg/L group（P〈0. 05 to P〈0. 01）. Correlation analysis showed the expression of serum hs-CRP was positively correlated with schizophrenia severity（P〈0. 05）. Conclusions：The serum levels of hs-CRP in schizophrenia patients significantly increased,and the clozapine treatment can upregulate the serum level of hs-CRP. The level of hs-CRP is correlated with psychotic state.