铜绿假单胞菌L型对第三代和第四代头孢菌素的药物敏感性研究

Study on drug sensitivity of Pseudomonas aeruginosa L-forms to the third and forth generation cephalosporins

目的:探讨铜绿假单胞菌(Pseudomonas aeruginosa,PA)L型对第三代和第四代头孢菌素敏感及耐药状况。方法:将PA诱导成稳定的L型,利用K-B纸片琼脂扩散法检测PA原菌及其L型对第三代和第四代头孢菌素的敏感程度,分析PA-L型的耐药状况。结果:PA-L型对第三代和第四代头孢菌素的抑菌圈直径均较原菌缩小(P<0.05),但仍维持在敏感程度。结论:PA-L型对第三代和第四代头孢菌素仍具有敏感性。

Objective：To study the drug sensitivity of L-forms of Pseudomonas aeruginosa（PA） to the third and forth generation cephalosporins. Methods：PA was induced into a stable L-form. The drug sensitivity of PA L-forms to the third and forth generation cephalosporins was analyzed by K-B drug sensitivity test. The change trend of drug sensitivity and resistance of PA L-forms was analyzed. Results：The inhibition zone of PA L-forms was smaller than that of their parent bacteria, and there had the significant difference（P〈0. 05）. But the drug sensitivity of L-forms of PA to the third and forth generation cephalosporins was still sensitive. Conclusions：The drug sensitivity of PA L-forms to the third and forth generation cephalosporins is still sensitive.