李可变通小青龙汤治疗肺部感染的临床研究

Clinical Study of Li Ke Adapted Xiao Qinglong Decoction in Treating Pulmonary Infection

【目的】观察中药李可变通小青龙汤治疗肺部感染(社区获得性肺炎)的疗效及安全性。【方法】将符合纳入标准的120例患者随机分成观察组和对照组,每组各60例。观察组给予中药李可变通小青龙汤治疗,对照组给予常规西医治疗,观察2组患者治疗前后发热消退时间、单项症状积分、白细胞(WBC)计数、C反应蛋白(CRP)水平、临床总体疗效积分等指标的变化情况,评价2组的总体疗效及用药安全性。【结果】(1)疗效方面:治疗后,2组患者发热、咳嗽、咯痰等单项症状积分和WBC计数、CRP水平及临床总体疗效积分等均较治疗前显著改善(P<0.01);组间比较,观察组患者咳嗽、咯痰、神疲乏力、饮食等症状积分改善优于对照组(P<0.05或P<0.01);但发热消退时间、WBC计数、CRP水平、临床总体疗效积分及总体疗效等2组无显著性差异(P>0.05)。(2)安全性方面:在7 d的临床观察中,观察组所有病例均未发现心慌、胸闷、黄疸、少尿等心、肝、肾功能损害的临床症状,检测肝功能、肾功能、尿常规、心电图等,均无异常改变。【结论】李可变通小青龙汤治疗肺部感染具有较好疗效,特别是在改善咳嗽、咯痰、神疲乏力、饮食等症状方面,其疗效优于西医对照组。

Objective To observe the therapeutic effect and safety of Li Ke Adapted Xiao Qinglong Decoction, an experienced formula adapted from the classic recipe of Xiao Qinglong Decoction by practitioner Li Ke, for the treatment of pulmonary infections （ community acquired pneumonia ）. Methods One hundred and twenty community acquired pneumonia patients were randomly divided into observation group and control group, 60 cases in each group. The observation group was treated with Li Ke Adapted Xiao Qinglong Decoction, and the control group was treated with routine western medicine. Before and after the treatment, the outcomes of fever subsiding time, single symptom scores, white blood cell（WBC）count, C-reactive protein（CRP）level, and the integral of the overall clinical efficacy were collected for the evaluation of clinical efficiency and safety. Results （1）After treatment, the scores of fever, cough and expectoration, WBC count, CRP level and the integral of the overall clinical efficacy of the two groups were much improved （P 〈 0.01 ）. And the observation group had better effect on improving the scores of cough, expectoration, fatigue and weakness, and dietary disorder than the control group （P 〈 0.05 or P 〈 0.01）. However, the differences of fever subsiding time, WBC count, CRP level , the integral of the overall clinical efficacy and the overall clinical efficacy were not significant between the two groups after the treatment（P 〉 0.05）. group showed no manifestations of palpitation, chest in the examination of hepato-renal function, urine （2）During the observation period of 7 days, the observation distress, jaundice, oliguria, neither had abnormal changes and electrocardiography. Conclusion Li Ke Adapted Xiao Qinglong Decoction is effective for the treatment of pulmonary infections, and is more effective on relieving cough, expectoration, fatigue and weakness, and dietary disorder than western medicine