中药穴位贴敷法缓解女性学生原发性痛经的效果研究

Effect of Chinese Medicine Acupoint Application on Alleviating Primary Menstrual Pain in Students of One Traditional Chinese Medicine College

【目的】探讨中药穴位贴敷在缓解女性学生的原发性痛经经期疼痛和减轻其症状的作用。【方法】采用前瞻性随机交叉双盲临床试验。在两阶段的临床试验中,随机将来自某中医大学院校的60例原发性痛经学生分成试验组和对照组,每组各30例。2组均给予服用芬必得缓释胶囊的基础治疗。在第一阶段,试验组接受对关元穴(CV4)和神阙穴(CV8)的中药穴位贴敷治疗,对照组接受不使用中药(安慰剂疗法)仅在相应穴位进行贴敷的治疗。进行2个月经周期的干预后停止干预,间隔3个月经周期以清洗周期循环。第二阶段,将试验组与对照组的干预措施对调。分别于试验前和试验后使用视觉模拟评分表(VAS)、语言评价量表(VRS)、数字评价量表(NRS)、行为疼痛测定表(BRS-6)、疼痛评定指数量表(PRI)及回顾性症状量表(RSS)评价疗效。【结果】经第一阶段2个月经周期治疗后,试验组对VAS、BRS-6、PRI、NRS、VRS量表评分的改善作用均优于对照组,差异均有统计学意义(P<0.05或P<0.01)。经第二阶段的2个月经周期治疗后,对照组对VAS、BRS-6、PRI、NRS、VRS量表评分的改善作用均优于试验组,差异均有统计学意义(P<0.05或P<0.01)。【结论】中药穴位贴敷能有效地缓解女性学生的原发性痛经经期疼痛和痛经症状。

Objective To investigate the effect of acupoint application with Chinese medicine on alleviating menstrual pain and relieving the symptoms of dysmenorrhea in a cohort of traditional Chinese medicine college students in China. Methods A prospective randomized double-blind clinical trial of crossover design was carried out. In the two-phase study, a total of 60 female students with menstrual pain in a traditional Chinese medicine college of China were randomly allocated into treatment group and control group, 30 cases in each group. Two groups were given Ibuprofen Sustained-release Capsules. And additionally, at the first intervention phase the treatment group received acupoint application on the points of Guangyuan （CV4） and Shenque （CV8） with Chinese medicine, and the control group received acupoint application on the same points without any medicine. The intervention of the first phase lasted for 2 menstrual cycles and then followed by an interval of suspension for 3 menstrual cycles. At the second intervention phase, the intervention for the two groups was exchanged. The clinical efficiency was evaluated by the outcomes of the scores of Visual Analogue Scale （VAS）, Verbal Rating Scale （VRS）, Numerical Rating Scale （NRS）, the 6-point Behavioral Rating Scale-6 （BRS-6）, Pain Rating Index （PRI） and Retrospective Symptom Scale（RSS） before and after trial. Results After the first intervention phase for 2 menstrual cycles, the scores of VAS, BRS-6, PRI, NRS and VRS of the treatment group were much improved, and the differences were significant as compared with those of the control group （P 〈 0.05 or P 〈 0.01 ）. After the second intervention phase for 2 menstrual cycles, the improvement of the scores of VAS, BRS-6, PRI, NRS and VRS of the control group was superior to that of the treatment group, and the differences were significant （P 〈 0.05 or P 〈 0.01 ）. Conclusion The results suggested that acupoint application with Chinese medicine is effective on alleviating menstrual symptoms.