胸腔闭式引流联合白细胞介素-2胸腔内注入治疗顽固性气胸的临床分析

Clinical analysis of thoracic closed drainage combined with IL-2 injection into the thoracic cavity in treatment of intractable pneumothorax

目的观察胸腔闭式引流联合白细胞介素(IL)-2胸腔内注入治疗顽固性气胸的临床效果。方法选取我院确诊为顽固性气胸患者105例作为研究对象,按随机数字表法分为A组、B组、C组各35例,A组采用胸腔闭式引流治疗,B组采用IL-2胸腔内注入治疗,C组采用胸腔闭式引流联合IL-2胸腔内注入治疗。观察3组患者漏气终止、肺复张和拔管时间、临床疗效以及并发症发生率。结果 C组终止漏气、肺复张以及拔管时间均少于A组和B组(P<0.05),而A组和B组各项数据比较,差异具有统计学意义(P<0.05);C组总有效率91%高于B组71%与A组63%(P<0.05),B组与A组总有效率比较差异无统计学意义(P>0.05);C组并发症发生率11%低于B组23%与A组29%(P<0.05),B组与A组差异无统计学意义(P>0.05)。结论采用胸腔闭式引流联合IL-2胸腔内注入治疗顽固性气胸可有效降低并发症发生率,提高临床治疗效果。

Objective To observe clinical effect of thoracic closed drainage combined with IL-2 injection into the thoracic cavity in treatment of intractable pneumothorax. Methods One hundred and five cases of patients with intractable pneumothorax in our hospital were selected as the subjects, and were divided into A, B and C groups randomly, thirty-five cases in each group. A group were given closed thoracic drainage treatment, B group were given IL-2 thoracic injection treatment, and C group were given thoracic closed drainage combined with IL-2 thoracic injection treatment. The termination of air leakage, pulmonary rehabilitation and extubation time, clinical effect and incidence rate of complications were observed in the three groups. Results The termination of air leak- age, pulmonary rehabilitation and extubation time in C group were less than those in B and C groups （P〈0.05）. The total effective rate was 91% in C group, which was higher than that of 71% in B group and that of 63% in A group （P〈0.05）. There was no significant difference between B and A groups （P〈0.05）. The incidence rate of complications in group C was 11%, which was lower than that of 23% in B group and that of 29% in A group （P〈0.05）, and there was no significant difference between B and A groups （P〈0.05）. Conclusion The application of closed drainage of thoracic cavity combined with IL-2 injection into the thoracic cavity in the treatment of intrac- table pneumothorax can effectively reduce the incidence rate of complications and improve the clinical effect.