奥希替尼合成路线图解

Graphical Synthetic Routes of Osimertinib

奥希替尼是一种抗肺癌新药,用于治疗表皮生长因子受体(EGFR)突变,且对表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)产生耐药性的非小细胞肺癌患者,是目前唯一的治疗EGFR T790M突变阳性的转移性非小细胞肺癌的药物。文章综述了奥希替尼及其中间体的合成,以期为奥希替尼及其中间体的合成研究及生产提供参考依据。

Osimertinib is a new anti cancer drug, which used for the nonsmall-cell lung cancer patients with mutation of cpidermal growth factor receptor （EGFR） and drug fast of growth factor receptor tyrosine kinase inhibitor （EGFR-TKI）, and it is the only drug for the nonsmall-cell lung cancer with EGFR T790M mutation currently. The paper reviews the synthetic routes of Osimertinib and its intermediates, in order to referencc for the synthesis research and production.