康复新液对终末期肾脏病血液透析患者氨性口臭和口腔黏膜烧灼性疼痛的治疗效果研究

Treatment Effect of Kangfuxin Solution on Ammoniac Halitosis and Burning Pain in Oral Mucosa of Hemodialysis Patients with End-stage Renal Disease

目的探讨康复新液对终末期肾脏病(ESRD)血液透析患者氨性口臭和口腔黏膜烧灼性疼痛的治疗效果。方法于2013年1—10月,在徐州医学院附属医院接受血液透析治疗的110例ESRD患者中选取存在氨性口臭〔口气感官值(OS)≥2分〕的患者63例,采用随机数字表法分为对照组(n=31)和试验组(n=32)。两组患者均接受口腔卫生指导和漱口液使用培训,对照组患者选用复方氯己定含漱液,试验组患者选用康复新液,治疗时间为2周。检测并比较两组患者治疗前后的氨性口臭指标〔包括OS、口腔氨值(OAV)、唾液p H值〕、其他口腔检查情况〔包括舌苔厚度(Tt)、舌苔面积(Ta)、色素指数(SI)〕,以及两组存在口腔黏膜烧灼性疼痛〔现在疼痛指数(PPI)≥1分〕患者的疼痛指标〔包括疼痛评级指数(PRI)、视觉模拟评分法(VAS)、PPI〕。结果两组患者OS、OAV、唾液p H值的治疗前后差值比较,差异无统计学意义(P>0.05)。共有PPI≥1分患者41例,试验组PPI≥1分患者PRI、VAS的治疗前后差值高于对照组,差异有统计学意义(P<0.05);而两组患者PPI的治疗前后差值比较,差异无统计学意义(P>0.05)。两组患者Ta、Tt、SI的治疗前后差值比较,差异无统计学意义(P>0.05)。结论康复新液可以缓解ESRD血液透析患者的口腔黏膜烧灼性疼痛,效果优于复方氯己定含漱液;但其在治疗氨性口臭方面与复方氯己定含漱液相比并无优势。

Objective To discuss the treatment effect of kangfuxin solution on ammoniac halitosis and burning pain in oral mucosa of hemodialysis patients with end- stage renal disease（ ESRD）. Methods Among the 110 ESRD patients who received hemodialysis in the Affiliated Hospital of Xuzhou Medical University,63 patients with ammoniac halitosis（ OS ≥2）were selected from January to October of 2013. The patients were divided into control group（ n = 31） and experiment group（ n= 32） by random number table method. Patients in both of the two groups received oral hygiene instruction and training of using mouthwash,patients in control group used compound chlorhexidine gargle,while patients in experiment group chose kangfuxin solution,and the treatment time lasted for 2 weeks. The ammoniac halitosis indicators 〔including OS, oral ammonia value（ OAV）,p H value of saliva〕,other oral examinations conditions 〔including thickness of the tongue（ Tt）,area of the tongue（ Ta）,staining index（ SI） 〕of patients in two groups,and pain index 〔including pain rating scale（ PRI）,visual analogue scale（ VAS）,present pain index（ PPI） 〕of those patients with burning pain in the oral mucosa（ PPI≥1） were detected and compared before and after treatment in both groups. Results There was no significant difference in OS,OAV and p H of saliva between patients in two groups before and after treatment（ P 〉 0. 05）. The number of patients with PPI≥1 were 41 in total,the difference before and after treatment of PRI and VAS of patients with PPI≥1 in experiment group were significantly higher than that in control group（ P 〉 0. 05）. There was no significant difference in the PPI difference before and after treatment of patients in two groups（ P〈 0. 05）. The differences before and after treatment of Ta,Tt and SI were not significantly different（ P 〉0. 05）. Conclusion Kangfuxin solution can alleviate burning pain in oral mucosal of ESRD hemodialysis patients with ESRD,and its effect is better than chlorhexidine solution; but it has no advantage in the treatment of ammonia halitosis compared with chlorhexidine solution.