间充质干细胞应用于类风湿关节炎组织修复的研究进展

Research Prognosis of Application of Mesenchymal Stem Cells in the Tissue Repair of Rheumatoid Arthritis

类风湿关节炎(RA)是以滑膜炎及其所致的关节损伤为特征的自身免疫性疾病,现有的治疗方法多是通过药物抑制滑膜炎,而修复关节破坏的疗效甚微。由于间充质干细胞(MSC)是一类具有免疫调节作用,兼具多向分化潜能的干细胞,因此研究者希望通过其在抑制关节炎的同时,修复关节损伤。目前已有将MSC用于RA患者或动物模型治疗的研究报道,但研究结果存在分歧,且关于改善关节破坏的研究相对较少。本文主要总结MSC在RA组织修复中的研究进展,为临床治疗提供参考。

Rheumatoid arthritis（ RA） is an autoimmune disease characterized by synovitis and articular injury due to synovitis. The current available treatments for RA mainly control synovitis, but have little effects on articular destruction repair. Mesenchymal stem cells（ MSC） have effects on immunological regulation,and have the ability of multiple differentiation potential,so MSC have the potential to control synovitis and repair articular destruction. Until now, some researchers have reported the application of MSC in the treatment of RA patients or RA animal models, while these studies lead to different conclusions,and few studies focused on the effects of articular destruction. The studies on application of MSC in the tissue repair of RA are summarized in this article,which may provide the reference for clinical treatment.