尖吻蝮蛇血凝酶对颅脑手术术中出血的影响

Influence of hemocoagulase agkistrodon on intraoperative hemorrhage of craniocerebral operation

目的观察尖吻蝮蛇血凝酶对颅脑手术术中出血的影响。方法 46例颅脑手术患者,将其按入院顺序随机分为血凝酶组与对照组,各23例。血凝酶组常规给予颅脑手术,于术前30 min和术后第1天分别静脉注射注射用尖吻蝮蛇血凝酶2 U。对照组手术治疗和术中术后用药与血凝酶组相同,但术前不给予注射用尖吻蝮蛇血凝酶。观察两组术中出血及术后24 h引流量等。结果血凝酶组术中出血量(431.1±20.1)ml,术后24 h引流量(98.2±32.0)ml,均明显少于对照组的(622.0±55.6)ml、(140.1±36.0)ml(P<0.05)。结论术前静脉注射尖吻蝮蛇血凝酶,可通过减少出血量从而降低术后并发症发生率,值得在临床上广泛推广和应用。

Objective To observe influence of hemocoagulase agkistrodon on intraoperative hemorrhage of craniocerebral operation. Methods A total of 46 patients receiving craniocerebral operation were divided by admission order into hemocoagulase group and control group, with 23 cases in each group. The hemocoagulase group received conventional craniocerebral operation and 2U hemocoagulase agkistrodon for injection by intravenous injection in preoperative 30 min and postoperative 1 d. The control group received same operation and hemocoagulase dose during operation, without hemocoagulase agkistrodon injection before operation. Observation was made on intraoperative hemorrhage and postoperative 24 h drainage volume in both groups. Results The hemocoagulase group had obviously less intraoperative bleeding volume as（431.1±20.1）ml and postoperative 24 h drainage volume as（98.2±32.0）ml than（622.0±55.6） and（140.1±36.0）ml in the control group（P〈0.05）. Conclusion Preoperative intravenous injection of hemocoagulase agkistrodon can reduce incidence of postoperative complications through decreased bleeding volume. It is worth widely clinical promotion and application.