岩藻糖基化与肿瘤

Role of Fucosylation in Cancer

岩藻糖基化是重要的糖基化修饰方式,在哺乳动物中发挥重要作用,其参与ABO血型H抗原、Lewis血型抗原形成、选择素介导的白细胞外渗或归巢、宿主病原相互作用及信号通路修饰。在多种肿瘤中存在岩藻糖基化异常,其在肿瘤生长、侵袭、转移、免疫逃逸以及药物敏感性方面发挥重要作用,与肺癌的发生发展及预后密切相关。因此,靶向肿瘤中异常岩藻糖基化可能成为治疗肿瘤的新策略。本文将对岩藻糖基化在肿瘤发生发展中的作用进行综述。

Fucosylation is one of the most important glycosylation in mamal, involving biosynthesis of blood H antigen and Lewis antigen, selectin mediated intravasion and homing of leukocyte, host-microbe interactions, modification of signaling. Alterations in the expression of fucosylated oligosaccharides have been observed in several cancer, playing a role in proliferation, invasion, metastasis, immune escape and drug-sensitiity, especially in lung cancer. Targeting the abnormality of fucosylaion in cancer will become a new strategy. The role of fucosylation in cancer will be reviewed in this article.