柴胡桂枝干姜汤加减联合西药治疗冠脉痉挛性心绞痛60例临床观察

Clinical Observation on Treating 60 Cases with Coronary Artery Spasm Angina by Using Chaihu Guizhi Ganjiang Decoction Combined with Western Medicine

目的:观察柴胡桂枝干姜汤加减联合西药治疗冠脉痉挛性心绞痛的临床疗效。方法:60例以冠脉痉挛为主要方式诱发的心绞痛患者随机分为治疗组与对照组各30例。对照组患者予缓解痉挛、抗血小板凝聚、扩冠、降脂、控制心率等西医常规治疗。治疗组在对照组基础上给予柴胡桂枝干姜汤加减,每日1剂,两组连续治疗4周,分别比较两组临床、心电图疗效及中医症候改善情况。结果:心绞痛临床疗效比较,治疗组总有效率86%优于对照组53%,两组统计学分析有显著差异(P<0.05)。治疗组心电图有效率66%,对照组有效率33%,两组统计学分析有显著差异(P<0.05)。中医临床症状疗效比较,治疗组有效率93%,对照组有效率36%,两组统计学分析有显著差异(P<0.05)。结论:柴胡桂枝干姜汤加减联合西药治疗能有效缓解冠脉痉挛、改善临床症状。

Objective： To observe the clinical curative effect of treating coronary artery spasm angina with Chaihu Guizhi Ganjiang Decoction to add and subtract in combination with the western medicine. Methods： 60 patients with angina pectoris induced by coronary artery spasm were randomly divided into a treatment group and a control group, with 30 cases in each. The patients in the control group were given conventional treatment with western medicine for relieving spasm, antiplateletion, anticoagulafion, vasodilatation, lowering blood-fat and controlling heart rate, and etc. While the patients in the treatment group received the same treatment as well as Chaihu Guizhi Ganjiang Decoction to add and subtract once a day. Clinical effect, ECG effect and improvement of TCM symptoms of the two groups were compared after four weeks treatment. Results： For treating angina pectoris, the total curative rate of the treatment group was 86%, which was higher than that of the control group, which was 53%. There were significant differences between the two groups （P 〈0. 05）. ECG effective rate was 66% in treatment group and 33% in the control group, with significant difference （P 〈0. 05）. The rate of clinical curative effect of TCM symptoms was 93% in the treatment group, and 36% in the control group with significant difference （P 〈 0. 05 ）. Conclusion： Combined with western medicine, Chaihu Guizhi Ganjiang Decoction to add and subtract can effectively alleviate coronary spasm and improve clinical symptoms.