HPV18 DNA replication inactivates the early promoter P_(55) activity and prevents viral E6 expression

Dear Editor,Human papillomaviruses(HPV)are a large group(>200genotypes)of small double-stranded DNA viruses(https://pave.niaid.nih.gov/).Although infections by most HPV types are asymptomatic,persistent infections in cervical and ano-genital epithelia by high-risk

Dear Editor, Human papillomaviruses （HPV） are a large group （〉 200 genotypes） of small double-stranded DNA viruses （https：//pave.niaid.nih.gov/）. Although infections by most HPV types are asymptomatic, persistent infections in cervical and ano-genital epithelia by high-risk HPV can lead to the development of cervical and ano-genital intraepithelial neoplasia and invasive carcinoma. Of 15 known high-risk HPV types, HPV16 and HPV18 are the two most common types inducing the development of cervical, anal, and a small portion of oropharyngeal cancers and are found in -70% of cervical cancer cases worldwide （Munoz et al., 2003）.