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枢经活络按摩膏镇痛作用的药理研究

Pharmacological research on effect of Shujing Huoluo massage-paste on analgesia
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摘要 目的:观察枢经活络按摩膏的镇痛效果。方法:实验一将合格20只小鼠随机分为枢经活络按摩膏组、空白对照组,10只/组。枢经活络按摩膏组小鼠两后足分别涂上枢经活络按摩膏组,对照组涂医用凡士林,用恒温水浴将热板温度控制在(55±5)℃进行痛阈测定,分别于给药后分别于给药后30、60、90、120 min测定各组小鼠痛阈值。实验二将20只小鼠随机分为枢经活络按摩膏组和空白对照组。分别给两组小鼠腹部脱毛皮肤处经皮涂抹枢经活络按摩膏和等面积的医用凡士林,每天1次,连续7 d。末次给药后1 h,各鼠腹腔注射0.6%冰醋酸0.1 m L/10 g体重,记录注射冰醋酸后15 min内小鼠出现的扭体反应次数。结果:枢经按摩膏组给药后各个时间段的痛阈值均较给药前有所提升(P<0.05),且在给药后60 min、90 min、120 min几个时间段痛阈值较医用凡士林组高(P<0.05)。枢经按摩膏组小鼠扭体反应时间较医用凡士林组小鼠有所延迟,且枢经按摩膏组小鼠平均扭体反应次数较医用凡士林组有明显减少(P<0.05)。结论:枢经活络按摩膏具有较好的镇痛效果。 Objective: To observe the effect of Shujing Huoluo massage-paste on analgesia. Methods: Experiment 1: 20 qualified mouse were divided randomly into Shujing Huoluo massage-paste group and blank control group,10 mouse in each group. Two rear feet of mouse in Shujing Huoluo massage-paste group were applied respectively with Shujing Huoluo massage-paste,while those in control group were applied with medicinal vaseline. The temperature of hot plate was controlled at( 55 ± 5) ℃ by thermostatic water bath,and the pain threshold was measured. Respectively at 30,60,90 and 120 min. after administration,the pain thresholds of mouse in each group were measured. Experiment2: 20 qualified mouse were divided randomly into Shujing Huoluo massage-paste group and blank control group. The depilated abdominal skins of mouse in two groups were applied respectively with Shujing Huoluo massage-paste and medicinal vaseline of equal area,1 time per day,continuously for 7 d. At 1 h after the last administration,the abdominal cavity of each mice was injected with 0. 6% glacial acetic acid at 0. 1 m L/10 g body weight,and the number of body writhing response of mice was recorded during 15 min. after intraperitoneal injection of glacial acetic acid. Results: In Shujing Huoluo massage-paste group,the pain thresholds of various time periods after administration all were raised compared with those before administration(P〈0. 05),and the pain thresholds during several time periods of 60,90 and 120 min. after administration all were higher than those in medicinal vaseline group(P〈0. 05). The time of body writhing response of mice in Shujing Huoluo massagepaste group was delayed compared with that of mice in medicinal vaseline group,and the average number of body writhing response of mice in Shujing Huoluo massage-paste group was reduced obviously compared with that in medicinal vaseline group(P〈0. 05). Conclusions: Shujing Huoluo massage-paste has the effect on analgesia.
出处 《山西中医》 2016年第11期51-52,共2页 Shanxi Journal of Traditional Chinese Medicine
关键词 枢经活络按摩膏 药理 疼痛 实验研究 Shujing Huoluo massage-paste pharmacology pain experimental research
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