阿奇霉素治疗小儿呼吸道感染的临床疗效及对炎症因子的影响

Azithromycin treatment efficacy and effects on inflammatory mechanisms of respiratory infections in children

目的:考察阿奇霉素治疗小儿呼吸道感染的临床疗效及对炎症因子的影响。方法:将呼吸道感染患儿80例随机分为对照组与研究组各40例,对照组给予头孢拉定60 mg/kg·d-1,静脉滴注,1次/d,连续5 d;研究组给予阿奇霉素颗粒10 mg/kg·d^(-1),口服,1次/d,持续5d。比较两组总有效率,观察治疗前后患者血清白介素-4(IL-4)、白介素-6(IL-6)、白介素-6(IL-10)的变化,记录两组药物不良反应发生情况。结果:研究组总有效率(92.50%)明显高于对照组(72.50%),有显著性意义(P<0.05);两组治疗5d患儿血清IL-4、IL-6、IL-10较治疗前降低,均有显著性意义(P<0.05);研究组治疗5d患儿血清IL-4、IL-6、IL-10低于对照组,且均有显著性意义(P<0.05);治疗期间两组患儿均未见明显不良反应。结论:阿奇霉素治疗小儿呼吸道感染疗效显著,可降低患儿血清IL-4、IL-6和IL-10水平,且安全性良好。

Objective： To analyze the efficacy of azithromycin and its effect on inflammatory mechanisms of respiratory infection in children. Methods： Eighty cases of children with respiratory infection were randomly divided into control group and study group,forty cases of children in each group. For the control group,cefradine was intravenously infused at a dose of 60 mg / kg·d-1daily for five days. For the trial group,azithromycin granules was orally given at a dose of 10 mg / kg·d-1daily for five days. Results：The total effective rate for the trial group was 92. 50%,which was higher than that for the control group（ 72. 50%）（ P〈 0. 05）.The levels of IL-4,IL-6,IL-10 in serum after a five-day treatment in the trial group were lower than those before the treatment and the control group,respectively（ P 〈0. 05）. No obvious adverse effects were observed in the two groups. Conclusion：Azithromycin is greatly effective in the treatment of pediatric respiratory infection and can reduce the serum levels of IL-4,IL-6 and IL-10 with a satisfactory safety.