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非编码RNA与心脏纤维化的研究进展

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摘要 心脏的应激状态可激活心脏成纤维细胞,使其产生过多的细胞外基质,形成纤维组织,最终导致心脏结构改变及心脏衰竭。目前心脏纤维化的发生机制还不明确,其过程涉及诸多因素。非编码RNA是一类内源性RNA分子,主要包括微小RNA和长链非编码RNA等,参与细胞的生长、增殖和分化,在心血管疾病的发生发展过程中起着重要的调节作用。该文介绍了非编码RNA在心脏纤维化中的研究进展。
出处 《国际心血管病杂志》 2016年第6期348-350,共3页 International Journal of Cardiovascular Disease
基金 国家自然科学基金(81470592 81400207)
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