消瘀散及其拆方治疗急性软组织挫伤的实验研究

Experimental Research of Xiaoyusan and Its Decomposition for Treating Acute Soft Tissue Injury

目的:观察消瘀散及其拆方对急性软组织挫伤的疗效差异,选取治疗急性软组织挫伤最优的中药复方。方法:通过正交t值法主药分析表将消瘀散拆方分为12组(其中拆方组11组为A^E和G^L组,全方组为F组),将72只新西兰大白兔造成急性软组织挫伤模型后,随机分配到12组中,各组用药后第3,5天做大体观察评分、光镜下组织病理评分、血液流变检测和血清IL-1β及IL-6含量测定,评分数据用SPSS 17.0统计软件统计。结果:第3,5天各组间的大体观察评分、光镜下组织病理评分、血液流变检测和血清IL-1β及IL-6含量测定均有不同程度的降低,其中B组、K组及全方F组明显优于其余拆方组(P<0.01),K组、F组优于B组(P<0.05),K组、F组比较差异无统计学意义(P>0.05)。结论:B组、K组及全方组对治疗急性软组织挫伤均有较好的疗效,其中K组及全方F组疗效更佳。

Objective： To observe the therapeutic efficacy of Xiaoyusan ointment and its decomposition for treating acute soft tissue injury,in order to choose the optimization of Chinese herbal compound. Methods：Using orthogonal t value de- sign to decompose Xiaoyusan ointment into 12 groups （including 11 decomposition groups A- E and G- L, and Xiaoyusan ointment group F）. All 72 New Zealand rabbits, which were made the model Qf acute soft tissue injury,were divided into above 12 groups randomly. The general observation scores, histopathology scores under microscope, blood theology, and levels of serum IL-1β and IL-6 were detected at the third and the fifth day after the treatment. The score data were statisti- cal by SPSS 17. 0 statistical software. Results： The general observation scores, the histopathology scores, each index of blood theology,and levels of IL-1β and IL-6 were decreased in each group at the third and the fifth day. The group B, group K and group F were obviously better than the other decomposition groups（P〈0.01）. The group K and group F were obviously better than the group B（P〈0.05）. There was no statistical difference between group K and group F（P〈 0.05）. Conclusion： Group B,group K and group F have great therapeutic effect in treating acute soft tissue injury,and group K and group F are better.