5-HTTLPR基因多态性与糖尿病周围神经性疼痛疗效的关系

Relationship between the 5-HTTLPR gene polymorphism and the therapeutic effect of diabetic peripheral neuropathic pain

目的 探讨5-HTTLPR基因多态性与氟西汀治疗糖尿病周围神经性疼痛效果的关系。方法 选取我院2014年1月～2015年5月收治的48例糖尿病周围神经性疼痛患者作为研究对象,所有受试者均给予氟西汀治疗8周,采用聚合酶链反应（PCR）技术检测5-HTTLPR基因多态性。结果 入组基因分型L/L、L/S型和S/S型的患者分别为7、15和26例,治疗后的SF-MPQ分值为（18.3±3.9）分、（22.8±4.6）分和（25.4±5.4）分,分别低于治疗前的（45.3±5.2）分、（44.8±6.1）分和（45.7±4.9）分,差异有统计学意义（P〈0.05）;对应的SF-MPQ下降幅度分别为（26.2±3.7）分、（21.1±4.3）分和（20.6±5.1）分,与治疗前比较差异有统计学意义（P〈0.05）。L/L与L/S基因组的减分率〉50%,且L/L基因型组的减分率显著高于其他两组,差异有统计学意义（P〈0.01）。结论 5-HTTLPR基因多态性可能与氟西汀治疗糖尿病周围神经性疼痛的效果相关。

Objective To explored the relationship between the 5-HTTLPR gene polymorphism and the therapeutic effect of Fluoxetine in the treatment of diabetic peripheral neuropathic pain.Methods 48 patients with diabetic peripheral neuropathic pain in our hospital from January 2014 to May 2015 were selected and given Fluoxetine treatment for 8 weeks.The PCR technology was used to examine the 5-HTTLPR gene polymorphism.Results There were 7,15 and 26 cases in L/L,L/S and S/S genotypes,respectively.The scores of SF-MPQ were（18.3 ±3.9） points,（22.8±4.6） points,and（25.4±5.4）points after treatment of L/L,L/S and S/S patients,compared with the scores of（45.3±5.2） points,（44.8±6.1） points and（45.7±4.9） points before treatment,respectively,with significant difference（P〈0.05）.The corresponding reductions of SFMPQ was（26.2 ±3.7） points,（21.1 ±4.3） points and（20.6 ±5.1） points,respectively,and there was significant difference between after treatment and before treatment（P〈0.05）.The reduction rate of L/L and L/S genome were more than 50%,and the reduction rate of L/L genotype was higher than that the other two genomes,with significant difference（P〈0.01）.Conclusion 5-HTTLPR gene polymorphism may be associated with the effect of Fluoxetine in the treatment of diabetic peripheral neuropathic pain.