多普勒导丝评估心脏X综合征患者冠脉循环

Evaluation of Coronary Circulation of Patients with Cardiac Syndrome X by Doppler Guidewire

目的采用多普勒导丝评价心脏X综合征(CSX)患者的冠脉循环。方法采用多普勒导丝测定观察组(38例CSX患者)及对照组(12例健康对照)的冠脉循环生理学参数。结果观察组的冠脉血流储备(CFR)为1.83±0.21,明显低于对照组的2.67±0.28,差异具有统计学意义(P<0.05);观察组的微血管阻力指数(IMR)为(36.2±5.3)U,明显高于对照组的(21.2±4.7)U,差异具有统计学意义(P<0.05);两组的血流储备分数(FFR)比较差异无统计学意义(0.92±0.08 vs 0.94±0.06,P>0.05)。结论 CSX患者心肌微血管阻力增加导致冠脉血流储备功能障碍。

Objective To evaluate the coronary circulation of patients with cardiac syndrome X （CSX） by doppler guidewire. Methods The physiology indexes of coronary circulation of observation group （38 cases of CSX patients） and control group （12 cases of healthy people） were measured. Results The coronary flow reserve （CFR） of observation group was 1.83 ±0.21, significantly lower than 2.67 ± 0.28 of control group, with statistical difference （P 〈0.05）. The index of microvascular resistance （IMR） of observation group was （36.2 ± 5.3） U, significantly higher than （21.2± 4.7） U of control group, with statistical difference （P 〈0.05）. No statistical difference was found in the the fractional flow reserve （FFR） between two groups （0.92 ± 0.08 vs 0.94± 0.06, P 〉0.05）. Conclusions The dysfunction of coronary flow reserve in the CSX patients results from the increase of myocardial microvascular resistance.