更昔洛韦眼用凝胶和阿昔洛韦滴眼液治疗病毒性角膜炎的效果对比及对血清相关指标的影响

Effect Comparison of Ganciclovir Ophthalmic Gel and Aciclovir Eye Drops in Treatment of Viral Keratitis and the Influence on Serum-Related Indicators

目的对比更昔洛韦眼用凝胶和阿昔洛韦滴眼液治疗病毒性角膜炎的效果,并分析对血清相关指标的影响。方法选取我院2013年3月至2015年5月收治的病毒性角膜炎患者152例,随机分为观察组和对照组,各76例。对照组采用阿昔洛韦滴眼液,观察组采用更昔洛韦眼用凝胶。比较两组患者的临床效果及血清相关指标。结果观察组的临床总有效率为96.05%,显著高于对照组的81.58%,差异具有统计学意义(P<0.05);治疗3天、一周、两周后,两组的NO、GSH-Px、Zn值均依次增大,MDA和EGF值均依次减小,观察组的变化幅度优于对照组(P<0.05)。结论更昔洛韦眼用凝胶治疗病毒性角膜炎的疗效优于阿昔洛韦滴眼液,且对血清相关指标的影响更明显。

Objective To compare the effect of ganciclovir ophthalmic gel and aciclovir eye drops in treatment of viral keratitis and analyze the influence on serum-related indicators. Methods 152 cases of patients with viral keratitis admitted to our hospital from March 2013 to May 2015 were selected and randomly divided into observation group and control group, with 76 cases in each group. The control group was treated with aciclovir eye drops, while the observation group was treated with ganciclovir ophthalmic gel. The clinical effect and serum-related indicators of patients were compared between two groups. Results The clinical total effective rate of observation group was 96.05%, significantly higher than 81.58% of control group, with statistical difference （P〈0.05）. Three days, one week and two weeks after treatment, the NO, GSH-Px and Zn of two group gradually increased, the MDA and EGF gradually decreased, and the change range of observation group was better than that of control group （P〈0.05）. Conclusions Ganciclovir ophthalmic gel in the treatment of viral keratitis has better curative effect than aciclovir eye drops, with more significant influence on serum-related indicators.