奥美拉唑联合多潘立酮治疗小儿反流性食管炎的临床疗效观察

Observation of Clinical Effect of Omeprazole Combined with Domperidone in the Treatment of Children with Reflux Esophagitis

目的观察分析采用奥美拉唑联合多潘立酮治疗小儿反流性食管炎(RE)的效果。方法选取我院2013年1月至2015年12月收治的120例反流性食管炎患儿,随机分为观察组和对照组各60例。对照组采用奥美拉唑治疗,观察组采用奥美拉唑联合多潘立酮治疗。比较两组患儿的临床治疗效果。结果观察组的治疗总有效率为93.33%,显著高于对照组的75.00%(P<0.05);治疗后,观察组患儿的反流次数、时间、食管p H值显著优于对照组(P<0.05);两组患儿的不良反应发生率比较差异无统计学意义(P>0.05)。结论采用奥美拉唑联合多潘立酮治疗反流性食管炎患儿,有利于缓解临床症状,减轻患儿痛苦,提高治疗总有效率,不良反应发生率低,安全可靠,值得临床推广应用。

Objective To observe and analyze the effect of omeprazole combined with domperidone in the treatment of children with reflux esophagitis （RE）. Methods 120 cases of children with reflux esophagitis admitted to our hospital from January 2013 to December 2015 were selected and randomly divided into observation group and control group, with 60 cases in each group. The control group were treated with omeprazole, while the observation group were treated with omeprazole combined with domperidone. The clinical treatment effect of children were compared between two groups. Results The total effective rate of treatment of observation group was 93.33%, significant higher than 75.00% of control group （P 〈0.05）. The reflux times, time, esophageal pH of children in observation group were significant better than those of control group （P〈0.05）. No statistical difference was found in the incidence of adverse reactions between two groups （P〉0.05）. Conclusions Omeprazole combined with domperidone in the treatment of children with reflux esophagitis can alleviate the clinical symptoms, reduce the pain, improve the total effective rate of treatment, with low incidence of adverse reactions, and is safe and reliable, which is worthy of clinical promotion and application.