血清糖类抗原与癌抗原对胰腺癌诊断价值

Combined detection of serum carbohydrate antigens and CEA levels in patients with pancreatic cancer

目的探讨联合监测与胰腺癌相关的血清糖类抗原19-9(CA19-9)、糖抗原125(CA125)、糖抗原242(CA242)和癌胚抗原(CEA)在胰腺癌诊断中的价值。方法选取2012年1月至2014年4月武警辽宁省总队医院收治的胰腺癌患者110例设为观察组,同期100例健康体检者设为对照组。观察两组患者中血清CA19-9、CA125、CA242及CEA之间的差异,并分析单项检测和4项肿瘤标记物联合检测诊断胰腺癌的敏感性和特异性的差异。结果观察组患者血清CA19-9、CA125、CA242及CEA水平均高于正常对照组,组间比较,差异有统计学意义(P<0.05)。单独检测血清CA19-9、CA125、CA242和CEA时,4项指标的敏感性分别为75.5%、71.8%、70.9%、50.9%,特异性分别为78.0%、88.0%、89.0%、80.0%,联合测定时敏感性和特异性分别为95.4%、86.0%。结论胰腺癌患者血清CA19-9、CA125、CA242及CEA水平升高,联合4种肿瘤标记物的检测具有较高的敏感性和特异性,对胰腺癌具有较高的诊断价值。

Objective To explore the value of combined detection of serum carbohydrate antigen 19-9（ CA19-9）,carbohydrate antigen125（ CA125）,carbohydrate antigen242（ CA242） and CEA levels in patients with pancreatic cancer. Methods From January 2012 to April 2014,110 cases of patients with pancreatic cancer were collected and designed as the experimental group,and the other 100 healthy people with physical examination at the same time were designed as the control group. Levels of CA19-9,CA125,CA242 and CEA were detected between the groups,and the single or combined detection of the sensitivity and specificity of above 4 diagnostic indexes in detecting pancreatic cancer were conducted. Results Serum CA19-9,CA125,CA242 and CEA levels in the experimental group were higher than those in the control group（ P〈0. 05）. The single detection of the sensitivity of CA19-9、CA125、CA242 and CEA levels were 75. 5%,71. 8%,70. 9% and 50. 9%,respectively. Specificity were 78. 0%,88. 0%,89. 0% and 80. 0%,respectively. And combined detection of sensitivity and specificity of above 4 tumor makers were 95. 4% and 86. 0%. Conclusion Serum CA19-9,CA125,CA242 and CEA levels in patients with pancreatic cancer are significantly increased,combined detection of 4 tumor markers with high sensitivity and specificity,which has a high value of the diagnosis of pancreatic cancer.