摘要
BackgroundDiabetes mellitus (DM ) 与冠的动脉疾病(CAD ) 被联系前进。尽管以前的研究与 CAD 表明了类脂化合物和脂蛋白比率的协会，没有数据有关在类脂化合物和脂蛋白比率和在糖尿病患者的新发作 CAD 的严厉之间的关系当前是可得到的。因此，现在的学习的目的有新发作 CAD 的 380 个连续 T2DM 病人是在与类型 2 DM (T2DM ).MethodsA 在病人预言 CAD 的严厉调查类脂化合物和脂蛋白比率的实用性全部的在现在的学习被注册。然后，他们根据 Gensini 被分类进三个组分数(GS ) tertiles。在类脂化合物和脂蛋白比率之间的关系当前使用了， GS 与到 apoA 的 apolipoprotein B 是自然转变木头的 GS ( lnGS )的 investigated.ResultsPositive 关联--我比率( apoB/apoA-I )， non-high-density 脂蛋白胆固醇到 apoA --我比率( non-HDL-C/apoA-I )，并且低密度的脂蛋白胆固醇到 apoA --我比率( LDL-C/apoA-I )被发现( r = 0.18 ， 0.13 ， 0.12 ，分别地所有 P < ；0.05 ) 。Multivariate 逻辑分析为高 GS 作为最强壮的预言者显示了 apoB/apoA-I (或 = 5.67， 95% CI：1.45-23.92， P = 0.003 ) 。在操作 apoB/apoA-I 的典型曲线的接收装置下面的区域是 0.63 (95% CI：0.60-0.66， P = 0.001 ) 为预言高 GS。apoB/apoA-I 的最佳的截止值预言高 GS 与 61.2% 的敏感和 62.1%.ConclusionsLipid 和脂蛋白比率的特性是 0.72 可能为在 T2DM 病人预言新发作 CAD 的严厉是有用的，并且 apoB/apoA-I 在这张人口作为最重要的预言者出现。
Background Diabetes mellitus （DM） is associated with coronary artery disease （CAD） progression. Although previous studies have demonstrated the association of lipid and lipoprotein ratios with CAD, no data are currently available concerning the relationship between lipid and lipoprotein ratios and the severity of new on-set CAD in diabetics. Therefore, the aim of the present study was to investigate the usefulness of lipid and lipoprotein ratios in predicting the severity of CAD in patients with type 2 DM （T2DM）. Methods A total of 380 consecutive T2DM patients with new on-set CAD were enrolled in the present study. Then, they were classified into the three groups ac-cording to Gensini score （GS） tertiles. The relationship between lipid and lipoprotein ratios currently used and the GS was investigated. Results Positive correlations of natural log-transformed GS （lnGS） with apolipoprotein B to apoA-I ratio （apoB/apoA-I）, non-high-density lipoprotein cholesterol to apoA-I ratio （non-HDL-C/apoA-I）, and low-density lipoprotein cholesterol to apoA-I ratio （LDL-C/apoA-I） were found （r = 0.18, 0.13, 0.12, respectively, all P 〈 0.05）. Multivariate logistic analysis indicated apoB/apoA-I as the strongest predictor for high GS （OR = 5.67, 95% CI： 1.45-23.92, P = 0.003）. Area under receivers operating characteristic curve of apoB/apoA-I was 0.63 （95% CI： 0.60-0.66, P = 0.001） for predicting high GS. The optimal cutoff value of apoB/apoA-I to predict high GS was 0.72 with the sensitivity of 61.2% and the specificity of 62.1%. Conclusions Lipid and lipoprotein ratios might be useful for predicting the severity of new on-set CAD in T2DM patients, and the apoB/apoA-I appeared as the most significant predictor in this population.
基金
This work was partly supported by National Natural Scientific Foundation （81070171, 81241121）, Specialized Research Fund for the Doctoral Program of Higher Education of China （20111106110013）, Capital Special Foundation of Clinical Application Research （Z 121107001012015）, Capital Health Development Fund （2011400302）, and Beijing Natural Science Foundation （7131014） awarded to Dr. Jian-Jun LI.
