消化性溃疡气虚血瘀证的代谢组学研究

Study on Metabolomics of Peptic Ulcer Patients with Qi Deficiency and Blood Stasis

目的研究消化性溃疡气虚血瘀症的代谢组学特征,以代谢组学的角度,全面阐明该证型的物质化基础。方法选择2014年1月—2015年1月本院脾胃科收治的80例消化性溃疡患者为研究对象,将其设定为观察组,另取同期来本院行健康检查的正常者为对照组,收集受试者的血液,胃镜病理标本,实施病理表述和代谢组学研究,对结果使用多元化数据进行比较。结果和正常对照组相比,气虚血瘀组患者在血清代谢物图谱上存在显著差异。结论和正常人相比,气虚血瘀症在代谢谱上存在显著差异,这些差异化代谢产物可能为病症形成的物质性基础,在对患者进行临床诊断与治疗的过程中,将中医辨证理论与代谢组学全面结合,可起到辨别患者疾病严重程度,对于其疾病预后来讲,有着非常重要的现实意义,在很大程度上增加了诊断客观性,值得进一步推广使用。

Objective： To study the metabolomic characteristics of peptic ulcer patients with qi deficiency and blood stasis and clarify its？ material？ basis in terms of metabolomics. Methods ： 80 peptic ulcer patients who were ad- mitted to Stomach Section of our hospital from January 2014 to January 2015 were taken as the study objects and set as observation group while normal patients who came to have health check at our hospital at the same period were taken as control group. The blood, gastroscope pathological specimens, pathological expression and metabolomics studies of the subjects were collected. The results were compared by using of diversification data. Results： Compared with the nor- mal control group, the observation group showed significant differences in serum metabolic profile. Conclusion： Corn- pared with the normal people, the patients with qi deficiency and blood stasis have significant differences in the meta- bolic profile, and these differentiated metabolites may be material base of the disease formation. In the process of clini- cal diagnosis and treatment of the patients, the overall integration of TCM theory and metabolomics may differentiate the severity of the disease and has a very important practical significance for the prognosis of the disease, and signifi- cantly increases the diagnostic objectivity to large extent, worthy of further application.