血浆中葡聚糖动态检测在侵袭性真菌感染的诊断和药物疗效评价中的价值

Clinical Value for Dynamic Detection of Plasma Glucan in Diagnosis and Therapeutic Monitoring of Invasive Fungal Infection

目的:探讨血浆(1,3)-β-D-葡聚糖动态检测在侵袭性真菌感染的诊断和药物疗效评价中的价值。方法:采用微生物快速动态检测仪及动态真菌检测试剂盒定量检测40例疑似真菌感染患者的血浆(1,3)-β-D-葡聚糖的含量,并对应用抗真菌药物的患者进行血浆(1,3)-β-D-葡聚糖动态追踪监测,每次均与真菌培养法相比较。结果:40例患者血浆(1,3)-β-D-葡聚糖水平均大于100pg·m L-1时,真菌培养法16例阳性,有32例经抗真菌药物治疗后,血浆(1,3)-β-D-葡聚糖浓度显著降低。结论:血浆(1,3)-β-D-葡聚糖动态检测可用于侵袭性真菌感染的早期诊断,是有效评价抗真菌药物疗效的指标。

Objective： To study the contribution of dynamic detection of the plasma（1-3）-β-D-glucan to diagnosis and therapeutic monitoring of invasive fungal infection. Methods： The fungal detection instrument and fast dynamic microbial detection kit were used for quantitative detection of plasma（1,3）-β-D-glucan concentration in 40 cases of patients with suspected fungal infection. Dynamic monitoring of plasma（1,3）-β-D-glucan in patients with antifungal agents was conducted and the results were compared with those by the fungal culture method. Results： All 40 cases of patients had a plasma（1,3）-β-D-glucan level higher than 100 pg · m L-1, among which 16 cases were positive by the fungi culture method. 32 cases were treated with anti fungal drugs, and the plasma（1,3）-β-D-glucan concentration was significantly decreased. Conclusion： Dynamic detection of plasma（1,3）-β-D-glucan can be used for early diagnosis of invasive fungal infections, and is an effective index to evaluate the efficacy of antifungal drugs.