基于Meta分析的银杏达莫注射液治疗糖尿病肾病临床评价研究

Meta-analysis of Efficacy of Ginkgo Leaf Extract and Dipyridamole Injection in the Treatment of Diabetic Nephropathy

目的:科学评价银杏达莫注射液治疗糖尿病肾病的有效性和安全性。方法:全面系统检索中国知网、万方、维普、中国生物医学文献服务系统、Cochrane Library和Pub Med,收集银杏达莫注射液治疗糖尿病肾病的随机对照试验,检索时间为各数据库建库至2016年6月,采用Cochrane提供的偏倚风险评价工具对纳入研究进行质量评价,应用Rev Man 5.2软件进行统计分析。结果:共纳入30个研究,累计受试者2 045例。加用银杏达莫注射液的治疗组在降低24h尿清蛋白排泄率、血清肌酐、尿素氮、全血高切黏度、全血低切黏度、血浆黏度、总胆固醇、三酰甘油、餐后2h血糖、空腹血糖等临床指标方面疗效均优于对照组(P<0.05)。结论:在常规治疗基础上应用银杏达莫注射液治疗糖尿病肾病有较好的临床效果。

Objective：To systematically evaluate the effectiveness and safety of Ginkgo leaf extract and dipyridamole injection （GD） as one adjuvant therapy for treating diabetic nephropathy （DN）. Methods：Randomized controlled trials （RCTs） of DN treated by GD were searched in CNKI, Wanfang data, VIP, Web of Science, Cochrane Library, PubMed and SinoMed, which from the date of databases were built to June 2016. Cochrane Risk Assessment Tool was used to evaluate the methodological quality of the RCTs. The Review Manager 5.3 software was used to conduct the Meta-analysis of extracted data. Results：30 RCTs including 2 045 patients were included finally. Compared with control group, the therapeutic efficacy of experimental group was better in reducing 24h UAER, Scr, BUN, blood high viscosity, blood low viscosity, plasma viscosity, TC, TG, 2h PBG, FBG （ all P 〈 0.05）. Conclusion： Comparing with control group, the combine use of GD was more effective. KEY WORDS Ginkgo leaf extract and dipyridamole injection; Diabetic nephropathy; Meta-analysis