Delta阿片受体及其与原发性肝癌的关系

Research delta opioid receptor and its association with hepatocellular carcinoma

自阿片受体于上世纪90年代发现以来，一直倍受科学界瞩目。作为G蛋白偶联受体家族成员之一的delta阿片受体（DOR），阿片肽类物质是其内源性配体。其由细胞外的氨基端、7次跨膜区域以及细胞内羟基端构成的基本结构也为人熟知。近年来，科学的进步也为delta功能的深入研究奠定了相关基础。阿片受体在多种肿瘤中均有异常表达，而且在肿瘤的发生、发展过程中亦发挥着重要的作用。本文就delta阿片受体及其与原发性肝细胞癌的关系研究进展做一综述。

Opioid receptors have drawn highly attention to scientists since they were founded in the 1990s. As a member of G protein-coupled receptor family, opioid peptides are the endogenous ligands. It is well known to us that the basic structure consists of extracellular amino residues, seven transmembraue region and the hydroxyl residues of the cell. In recent years, the progress of science laid the foundation for further studies on the function of delta receptor. Aberrant expression of delta opioid receptor in a variety of tumors, and it plays an important role of the occurrence and development of tumors. This review describes the recent research advances on delta opioid receptor and its association with hepatocellular carcinoma.