依托泊苷、长春地辛和表阿霉素在输液中的配伍稳定性考察

Compatible stability of etoposide,vindesine and epirubicin for transfusion

目的:考察依托泊苷注射液、注射用长春地辛和注射用表阿霉素在输液中的配伍稳定性,为临床给药提供科学依据。方法:将依托泊苷注射液、注射用长春地辛和注射用表阿霉素在500 mL0.9%氯化钠注射液中配伍,分别考察在25℃和4℃的储存条件下,采用高效液相色谱法测定配伍溶液中依托泊苷、长春地辛和表阿霉素的含量并测定溶液的pH值及不溶性微粒的大小。结果:依托泊苷注射液、注射用长春地辛和注射用表阿霉素在25℃和4℃条件下48 h内配伍液pH值及不溶性微粒无明显变化,含量变化小于5%。结论:在25℃和4℃的储存条件下,3种药物在500 mL的生理盐水中稳定性好,临床上可将3种药物配伍使用。

OBJECTIVE To investigate compatible stability of etoposide,vindesine and epirubicin for transfusion to supply evidence of clinical rational medication.METHODS Changes of pH values and insoluble particles of three drugs were observed after mixed with 500 mL of 0.9% sodium chloride injection and their relative contents were determined by HPLC within 48 h under storage conditions of 25 ℃and4 ℃,respectively.RESULTS No significant changes were noted in pH values and insoluble particles contents of three drugs varied by less than5% within48 h under storage conditions of 25 ℃ and 4 ℃,respectively.CONCLUSION Etoposide,vindesine and epirubicin are stable in 0.9% sodium chloride injection and can be used clinically.