聚已内酯表面磷酸胆碱仿生改性的血液相容性研究

Hemocompatibility studies of polycaproactone surface grafted with biomimetic(2-methacryloyloxyethyl phosphorylcholine)

通过表面原子转移自由基聚合法(SI-ATRP)得到具有不同接枝密度的聚2-甲基丙烯酰氧乙基磷酰胆碱改性的聚己内酯薄片(PCL-g-PMPC)。用衰减全反射红外、扫描电镜及接触角直接或间接地证明表面接枝反应成功;并通过蛋白吸附、血小板粘附及凝血时间对其血液相容性进行了评价。结果表明,利用SI-ATRP法在PCL表面接枝一层具有仿细胞外层膜结构的PMPC能不同程度地提高PCL薄片的血液相容性。

Biomimetic poly（2-methacryloyloxyethyl phosphorylcholine）（poly（MPC））brushes with various den-sity were grafted to PCL membranes by surface-initiated atom transfer radical polymerization （SI-ATRP）.At-tenuated total reflection-Fourier transform infrared （ATR-FT-IR）,scanning electron microscopy and water contact angle were used to characterize the modified membranes.Compared with the pristine PCL membrane, the PMPC-grafted PCL membranes showed lower protein adsorption and suppressed platelet adhesion in some degree.At the same time,the activated partial thromboplastin time （APTT）for the modified membranes was slightly increased.These results indicated that the surface biomimetic modification by grafting PMPC brushes rendered the PCL membranes with good blood compatibility.