麻醉药物对肿瘤微转移影响及机制的研究进展

Research progress in effects and mechanisms of anesthesia on toumr micrometastasis

肿瘤因其高发病率及死亡率备受各国重视。目前实体肿瘤的治疗仍以手术切除为主,然而在围手术期受手术、麻醉等多方面因素影响,可能造成肿瘤细胞进入血液循环、淋巴道、骨髓甚至播散于各组织器官,形成微转移灶,增加术后肿瘤复发及转移风险,影响患者术后生存率。近年来研究发现,多数麻醉药均能影响患者免疫系统功能和肿瘤细胞的活性,从而影响肿瘤的微转移。文中就各种围手术期麻醉药物对肿瘤的影响及机制的研究进展予以综述,旨在探讨围手术期麻醉药物在肿瘤微转移中的作用。

Tumor,with its high morbidity and mortality,has been gained increasingly high attention from the world.Currently,the main treatment for solid tumor is still surgical resection,during which surgery,anesthesia and other factors may have such side effects as releasing tumor cells into blood,lymphatic,bone marrow even organs and then resulting in the formation of micrometastatic lesion,increasing the risk of tumor recurrence and metastasis and finally affecting the postoperative survival rate.Recently,studies have shown that most anesthetic agents can influence the function of immune system and the activity of tumor cells,and then impact the tumor micrometastasis.This paper will summarize the research progresses in the impacts of anesthetic agents on tumor micrometastasis during perioperative period.