氯吡格雷抵抗冠心病患者的个体化药学监护

Individualized pharmaceutical care of coronary artery disease patients with clopidogrel resistance

氯吡格雷抵抗是冠心病复发性血栓事件的最主要原因之一,发生机制与患者疾病状态、CYP2C19等基因多态性及合并用药存在相互作用等有关。临床药师通过参与冠心病患者的药物治疗,排查氯吡格雷抵抗患者,结合基因检测结果、疾病状态、药物相互作用等,协助医生优化抗血小板治疗方案,开展个体化药学监护,并建立氯吡格雷抵抗冠心病患者的药学服务路径。

Clopidogrel resistance was one of the coronary artery disease. The mechanism was related to most important causes of recurrent thrombotic events of the patients＇ comorbidities, gene polymorphisms and drug interactions. Clinical pharmacist participated in the therapy for coronary artery disease patients, and helped search for patients with clopidogrel resistance. Clinical pharmacist helped the physicians optimize antithrombotic therapies and provided individualized pharmaceutical care after analyzing genotypes, comorbidities and drug interactions. Finally, the pharmaceutical service paths of coronary artery disease patients with clopidogrel resistance were established.