摘要
目的：探讨血清肿瘤标志物人附睾蛋白4（HE4）、细胞角蛋白19片段（CYFRA21-1）和组织多肽特异性抗原（TPS）联合检测在非小细胞肺癌（NSCLC）早期诊断中的应用价值。方法：应用电化学发光法和ELISA分别测定NSCLC患者、肺部良性病变患者及健康对照组人员血清中HE4、CYFRA21-1和TPS水平．比较3组间HE4、CYFRA21—1和TPS水平与阳性率的差异．以及联合检测诊断NSCLC的敏感性及特异性。结果：（1）肺癌患者整体TPS、CYFRA21-1和HE4水平及I～Ⅱ期NSCLC患者HE4水平显著高于肺部良性病变患者及健康体检者（P〈0．05）；Ⅲ～Ⅳ期NSCLC患者TPS、CYFRA21-1和HE4水平高于I-ⅡNSCLC患者（P〈0．05）。（2）HE4、CYFRA21—1和TPS联合检测诊断NSCLC的敏感性较单项检测敏感性明显增高（P〈0．05）。结论：血清HE4检测比CYFRA21．1和TPS对于NSCLC有更高的早期诊断价值。血清HE4、CYFRA2I-1和TPS联合检测对于NSCLC的诊断较单一指标具有更高的诊断价值。
Objective To investigate the application of the combined detection of HE4 with CYFRA21-1 and TPS antigen in the early diagnosis of non-small cell lung cancer. Methods The electrochemilumineseence and ELISA were used to detect the levels of serum HE4, CYFRA21-1 and TPS in patients with non-small cell lung cancer, and patients with benign lung disease and the healthy controls. The differences of the serum HE4, CYFRA21-1 and TPS, and the positive rate among the three groups were compared. The sensitivity and specifici- ty of the different combined detection methods for NSCLC were analyzed. Results （1） The TPS, CYFRA21-1 and HE4 level in patients with lung cancer and the HE4 level in patients with the I-]I stage NSCLC were signif- icantly higher than those in patients with benign lung disease and in the healthy controls （P 〈 0.05, respective- ly）; The TPS, CYFRA21-1 and HE4 level in patients with the m-IV NSCLC were higher than those in the pa- tients with the I～Ⅱ NSCLC （P 〈 0.05）. （2）Compared with the single detection, the sensitivity of the combined detections of TPS, CYFRA21-1 and HE4 for the diagnosis of NSCLC was significantly increased （P 〈 0.05）. Conclusion Higher value of early diagnosis for NSCLC was shown in detection of the serum HE4 than the CYFRA21-1 and TPS. The combined detection of Serum HE4, CYFRA21-1 and TPS for NSCLC diagnosis showed higher diagnostic value than the single detection.
出处
《实用医学杂志》
CAS
北大核心
2016年第22期3721-3724,共4页
The Journal of Practical Medicine
