JNK信号通路在PM_(2.5)、粉尘和稀土颗粒致细胞损伤中作用的研究进展

Research Progress on Role of JNK Signal Pathway in Cell Injury Induced by PM2.5, Dust, and Rare Earth Particles

大气污染物中的PM_(2.5)和空气中的粉尘、稀土颗粒等是诱导心血管系统、呼吸系统等疾病发生的重要环境危险因素,目前研究发现颗粒物对肺组织的损伤除了与氧化损伤和炎性损伤有关外,还与c-jun氨基末端转移酶(JNK)信号通路有关。本文主要介绍JNK信号通路与PM_(2.5)、粉尘和稀土颗粒的损伤机制,明确JNK信号通路与其所致细胞损伤的具体机制,可能为临床上相关疾病提供新的分子治疗靶点。

Atmospheric pollutants such as fine particulate matter （PM2.s）, dust, and rare earth particles are critical environmental risk factors that may induce cardiovascular system diseases and respiratory system diseases. It is known that the potential mechanism of injury to lung tissue by particulate matters may include inflammation, oxidative stress, and c-jun N-termminal kinase （JNK） signaling pathway. This review summarized the relationship between JNK signal pathway and PM2.5, dust, rare earth particles. New molecular target for treatment of relevant diseases could be identified by understanding the specific cell damage mechanism of JNK signal pathway.