放射性口腔黏膜炎的研究进展

Research progress on radiation induced oral mucositis

放射性口腔黏膜炎（radiation-induced oral mucositis，ROM）是头颈肿瘤放疗中最常见的并发症，其发生率与同步化疗及分割方式相关。与黏膜炎相关的表现包括口腔疼痛、吞咽困难、进食减少以及继发性感染，严重时可导致治疗的中断，影响疾病的控制和患者生活质量。因此，ROM的预防和治疗十分重要。本文针对ROM的定义、流行病学、病理生理机制、临床表现、预防和治疗，就现有的材料进行综述。

Radiation-induced oral mucositis （ROM） is a major complication in radiotherapy of head and neck. Mucositis is related to concurrent chemotherapy as well as altered fractionation schedules. The clinical symptoms associated with mucositis include oral pain, oral intake reduced, and secondary infections, which may lead to treatment interruption, suboptimal disease control, and poor quality of life. Hence, prevention and management of ROM is very important. In this review, some recent topics in terminology, prevalence, pathophysiology, clinical appearance, prophylaxis and treatment of mucositis related to radiation therapy are discussed.